In the Medieval Islamic medicine texts climatic plans for systematizing accommodation and healthy housing environments has been proposed. Ancient physicians viewed the human health protection as the genuine goal of medicine pertinent to man's interaction and consistency with climatic environment, relying on ingredient adaptation of human temperament with the four natural elements. In this article the history of the ancients’ climatic knowledge concerning the human interaction with artificial and natural environments is surveyed based on the historical interpretation approach of medical texts. The findings of this study indicate that climatic life method and organization of housing environments based on geographic features and climatic alterations of locations have been the most salient treatments of physicians for human temperament moderation, health, and climatotherapy. From this perspective, human health dependens on dynamic participation and coordination of a human being with climatic variable conditions via changing in the way and place of life (shift) and the existence of physical backgrounds of these changes in architecture. A brief survey of Iranian housing architecture shows that weather status (wind) regarding temperature, humidity and purity rate– as the most conspicuous indispensable factor for health and cli matotherapy – has the key role in localization and organization of the cities and housing spaces.